منابع مشابه
Multiple Campylobacter Genomes Sequenced
0001 The recent discovery of a Hobbit-like hominid on the Indonesian island of Flores was startling in some respects—its rather modern existence, for one—but it represents a classic case of Darwinian evolution. For reasons that are not entirely clear, when animals make their way to isolated islands, they tend to evolve relatively quickly toward an outsized or pint-sized version of their mainlan...
متن کاملNUMTs in sequenced eukaryotic genomes.
Mitochondrial DNA sequences are frequently transferred to the nucleus giving rise to the so-called nuclear mitochondrial DNA (NUMT). Analysis of 13 eukaryotic species with sequenced mitochondrial and nuclear genomes reveals a large interspecific variation of NUMT number and size. Copy number ranges from none or few copies in Anopheles, Caenorhabditis, Plasmodium, Drosophila, and Fugu to more th...
متن کاملDetecting Repeat Families in Incompletely Sequenced Genomes
Repeats form a major class of sequence in genomes with implications for functional genomics and practical problems. Their detection and analysis pose a number of challenges in genomic sequence analysis, especially if the genome is not completely sequenced. The most abundant and evolutionary active forms of repeats are found in the form of families of long similar sequences. We present a novel m...
متن کاملThe Characterization of Twenty Sequenced Human Genomes
We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals with severe hemophilia A and ten "control" genomes. We summarize the number of genetic variants emerging from a study of this magnitude, and provide a proof of concept for ...
متن کاملWindowMasker: window-based masker for sequenced genomes
MOTIVATION Matches to repetitive sequences are usually undesirable in the output of DNA database searches. Repetitive sequences need not be matched to a query, if they can be masked in the database. RepeatMasker/Maskeraid (RM), currently the most widely used software for DNA sequence masking, is slow and requires a library of repetitive template sequences, such as a manually curated RepBase lib...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2014
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0114-7